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Xiapex® injection treatment for Peyronie’s disease

Xiapex® is an injection therapy that splits the plaque, thus reducing penile curvature. The effectiveness of this therapy has been proven, but not everyone benefits to the same extent.


Unfortunately, the distribution of the collagenase of the bacterium Chlostridium histolyticum (Xiapex) has been discontinued worldwide by the pharmaceutical company at the end of 2019. Only in the United States of America the collagenase is still distributed. From today’s point of view, it is therefore impossible for us to continue to offer this effective therapy for the treatment of Peyronie’s disease. We ask for your understanding.

To qualify for applying this form of treatment, the attending physician needs to go through a certification process to be listed as specialist for Xiapex®.
Dr. Kuehhas is certificated for the use of Xiapex® and is one of the few urologists in Austria and Europe who uses the treatment method mentioned above. The results that have been achieved so far, have been promising. A successful result, however, can only be achieved through strong cooperation with the patient during the treatment.

What is Xiapex®?

Xiapex contains the collagenase Clostridium histolyticum which triggers enzymatic splitting of the existing plaque
The solution is carefully injected into the plaque through a thin needle. After successful injection, the patient is required to support loosening the plaque through additional physiotherapeutic steps, such as modeling of the penis.

– Plaque growth due to Peyronie’s disease –
Plaque causes a loss of elasticity which leads to the development of the curvature

Who is a suitable for Xiapex® injection treatment?

A correct assessment can only be done after examining your penis. Following an examination, Dr. Kuehhas will consult you whether Xiapex offers the right form of treatment for you.
Factors which reduce chances of successful treatment with Xiapex®:

  • Penile curvature of more than 60°
  • Ventral curvature (curvature facing downwards)
  • Signs of heavy calcification of the plaque.

How is Xiapex® injection treatment carried out?

At first, a treatment plan is created in accordance to the severity of Peyronie’s disease. It will include the number of Xiapex® injections necessary for a successful treatment. In support to the Xiapex® injections, penile modelling procedures are to be conducted by the patient. The patient will be instructed by Dr. Kuehhas. We recommend the use of penis extender devices, as the constant stretching of the penis helps further breaking up the plaque and supports the straightening process.

Can Xiapex® be used as an ambulatory treatment?

Yes, Xiapex® injections are an ambulatory treatment. It is not necessary for the patient to be admitted to a hospital for an overnight stay.

What if the treatment doesn’t bring the desired results?

In such cases, a surgical treatment might be the solution. Full straightening of the penis may be achieved through surgery.

What are the side effects associated with Xiapex® treatments?

The most common side effects seen with Xiapex are local injection site reactions such as bruising, blood blisters, swelling and pain. The most dreaded complication, a penis fracture, can only occur if the penile modelling procedures are not conducted properly. Effects, procedure and risks of Xiapex® injections will be fully explained prior to the treatment.

Choosing Xiapex® for treatment, what now?

If you are interested in the conservative treatment of Peyronie’s diseases with Xiapex®, do not hesitate to contact us.
We care about your concerns and would like to find the best solution for your problem!

Dr Franklin Kuehhas Dr Franklin Kuehhas is a medical specialist in the field of urology and andrology. He received his specialization training at the University College London. He also underwent his training at the prestigious University Hospital in Heidelberg (Germany) and at the University Hospital of Vienna (Austria). Dr Kuehhas focuses on the treatment of congenital and acquired penile curvatures (Peyronie’s disease). His research activities have resulted in many publications and improvements of surgical techniques such as the STAGE technique for penile curvature treatment.